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wiki:gynaecology:polycystic_ovary_syndrome [2020/06/16 16:47] djwiki:gynaecology:polycystic_ovary_syndrome [2020/06/18 08:07] (current) – removed dj
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-=====Polycystic Ovary Syndrome===== 
-Exact pathophysiology = unclear 
-  *often have raised testosterone 
-  *inappropriate gonadotrophin secretion - probably as a result of ovarian dysfunction rather than cause 
-  *most common hormonal abnormalities: excess Luteinising hormone (LH) and Insulin resistance 
- 
-Diagnostic criteria have varied over the years and vary according to authority group! Include the following: 
-  *evidence of ovarian dysfunction 
-  *exclusion of other disorders - eg other hormonal causes (Hypothyroidism, Hyperprolactinaemia, Cushing’s disease) 
-  *biochemical evidence of hyperandrogenism 
-  *?USS evidence 
- 
-Major features 
-  *menstrual dysfunction - usually a chronic pattern 
-  *anovulation 
-  *signs of hyperandrogenism - male hair distribution, acne 
-  *~50% are obese 
-  *Acanthosis nigricans - possibly due to insulin resistance 
-  *Hypertension 
-  *chronic pelvic pain 
- 
-treatments aimed at so-called metabolic derangements, such as anovulation, hirsutism, and menstrual irregularities. 
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-**References include:**\\  
-https://emedicine.medscape.com/article/256806-overview\\  
-https://teachmeobgyn.com/gynaecology/ovarian/polycystic-ovary-syndrome/\\