=====Ebola=====
  *Ebola virus disease (EVD), formerly known as Ebola haemorrhagic fever
  *natural hosts - thought to be fruit bats.
  *rare but severe, often fatal.
  *Average case fatality rate is around 50%. Has varied from 25% to 90% in past outbreaks.
  *spreads through human-to-human transmission via direct contact (through broken skin or mucous membranes) with:
    *Blood or body fluids from living or dead
    *Objects that have been contaminated with body fluids
    *ceremonial burials also a source

  *incubation period: 2-21/7.
  *not contagious unless symptomatic.
==Clinical==
Symptoms can be sudden and include:
  *Fever, Fatigue, Muscle pain
  *Headache, Sore throat
  *Vomiting, Diarrhoea
  *Rash
  *Symptoms of impaired kidney and liver function
    *internal and external bleeding

  *Ix: low WCC & platelet counts and elevated LFTs.
  *Specific labs:
    *antibody-capture enzyme-linked immunosorbent assay (ELISA)
    *antigen-capture detection tests
    *serum neutralization test
    *reverse transcriptase polymerase chain reaction (RT-PCR) assay
    *electron microscopy
    *virus isolation by cell culture.
==Treatment==
  *supportive primarily - trials with blood products, immunotherapies, antivirals
    *monoclonal antibodies (Inmazeb and Ebanga) have been approved
  *Ervebo vaccine is effective

==References include:==
[[https://www.who.int/news-room/fact-sheets/detail/ebola-virus-disease|WHO Ebola]]\\