Heart Failure
HFrEF
Goal of Heart Failure Mx - to prescribe combination of all at low initial doses and titrate to target/max tolerated doses (with doubling of doses), one at a time :
euvolaemic
- an angiotensin-converting enzyme (ACE) inhibitor, or if not tolerated, angiotensin receptor blocker (ARB) and
- a heart failure beta blocker then add
- a mineralocorticoid receptor antagonist (MRA)
hypervolaemic
- an angiotensin-converting enzyme (ACE) inhibitor, or if not tolerated, angiotensin receptor blocker (ARB) and
- a mineralocorticoid receptor antagonist (MRA) then when euvolaemic, add
- a heart failure beta blocker
ACEi Angiotensin-converting enzyme inhibitors | initial | target |
---|---|---|
enalapril | 2.5mg OD | 20mg OD |
lisinopril | 2.5mg OD | 50mg OD |
perindopril | 2.5mg OD | 10mg OD |
ramipril | 2.5mg bd | 5mg bd |
ARB Angiotensin receptor blockers | initial | target |
candesartan | 4mg OD | 32mg OD |
irbesartan | 75mg OD | 300mg OD |
losartan | 25mg OD | 100mg OD |
valsartan | 40mg bd | 160mg bd |
olmesartan | 10mg OD | 40mg OD |
β blockers | initial | target |
bisoprolol | 1.25mg OD | 10mg OD |
carvedilol | 3.125mg bd | 50mg bd |
nebivolol | 1.25mg OD | 10mg OD |
MRA Mineralocorticoid receptor antagonists | initial | target |
spironolactone | 25mg OD | 50mg OD |
eplerenone | 25mg OD | 50mg OD |
ARNI angiotensin receptor/neprilysin inhibitor | initial | target |
sacubitril/valsartan | 49/51 mg bd | 97/103 mg bd |
other | initial | target |
ivabradine | 5mg bd | 7.5mg bd |
STRATEGY:
- double the dose of each, one at a time, every 2–4/52(except MRAs; up-titrated in 4–8/52), or as tolerated.
- add the next drug before reaching target or maximum tolerated dose, eg, if the patient is euvolaemic, a heart failure beta blocker may be started before achieving target or maximum tolerated dose of an ACE inhibitor.
- clinical and lab review every 1–2/52 after each medicine initiation and dose increase,
If symptoms persist, consider:
- add hydralazine and nitrate (esp if Afro-Caribbean)
- digoxin for those is sinus
- for LVEF ≤ 35%, change ACE inhibitor (or ARB) to an angiotensin receptor-neprilysin inhibitor (ARNI).
- for LVEF ≤ 35%, add ivabradine for sinus HR>75
Heart failure with preserved ejection fraction (HFpEF)
- Clinical syndrome of signs and symptoms of HF as the result of high LV filling pressure despite normal or near normal LV ejection fraction (LVEF; ?50 percent). Most have normal LV volumes and an abnormal diastolic filling pattern.
- There is no clear evidence that pharmacologic therapy, diet, or other therapies reduce the risk of mortality in patients with HFpEF
- Condition commonly associated with HFpEF conditions are managed using approaches similar to those used to treat the general population or other forms of HF; there is no evidence for HFpEF-specific management of these conditions, including:
- HTN, atrial fibrillation (AF), coronary artery disease
- hyperlipidemia, obesity, anemia, diabetes mellitus, chronic kidney disease (CKD), and sleep-disordered breathing
Management strategy
- for those with HF & elevated pro-BNP – SGLT2 inhibitor 1st and, if tolerated, add MRA after 2/52 later
References include:
LOOP DIURETIC CONVERSION CHART | ||
---|---|---|
Loop diuretics | Oral | IV |
Furosemide (Lasix) | 40mg | 20mg |
Bumetanide (Bumex) | 1mg | 1mg |
Torsemide | 10-20mg | 10-20mg |
Heart Failure
Dx and Mx of HFpEF
https://www.uptodate.com/contents/treatment-and-prognosis-of-heart-failure-with-preserved-ejection-fraction/print#:~:text=INTRODUCTION%20Heart%20failure%20with%20preserved,)%20%5B1%2D5%5D.
https://www.nps.org.au/news/up-titrating-heart-failure-medicines
https://www.heartlungcirc.org/article/S1443-9506(18)31777-3/fulltext
SC furosemide
SC furosemide in HF
WestMidlands review
Trusts using:
Brighton
York
Doncaster
Scottish Highlands
Reliability: https://www.jhoponline.com/issue-archive/2022-issues/march-2022-vol-12-special-feature/19318-evaluation-of-the-reliability-of-5-fu-elastomeric-pump-in-an-ambulatory-infusion-center
the pumps for IV antibiotics
review elastomeric pumps, antibiotics
WestMidlands review
Trusts using:
Brighton
York
Doncaster
Scottish Highlands
Reliability: https://www.jhoponline.com/issue-archive/2022-issues/march-2022-vol-12-special-feature/19318-evaluation-of-the-reliability-of-5-fu-elastomeric-pump-in-an-ambulatory-infusion-center
the pumps for IV antibiotics
review elastomeric pumps, antibiotics